PYGO1

Across TCGA patient cohorts, PYGO1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGO1-associated genes across cancer lineages are PRAS40_pT246, PREX1, and CDK1. Each is linked with PYGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGO1-to-partner and partner-to-PYGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by PYGO1-low versus PYGO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO1→partner) and Y-score (partner→PYGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.223	+2.807	<.001	.003	3	2
UCEC	PREX1 →	-0.301	-3.459	.005	.005	3	2
UCEC	CDK1 →	+0.171	+2.000	.003	.030	3	2
UCEC	Di-Ras3 →	-0.209	-3.571	<.001	.002	3	2
UCEC	eEF2 →	+0.469	+2.807	<.001	.003	3	1
UCEC	eIF4G →	+0.321	+2.459	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

PRAS40_pT246 by PYGO1 expression — UCEC

Explore this box plot interactively →