PYGO1

Across TCGA cell cohorts, PYGO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,918 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PYGO1-associated GO terms across cancer lineages are Nuclear transport, Protein localization to nucleus, and Nucleocytoplasmic transport. Each is linked with PYGO1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PYGO1-to-partner and partner-to-PYGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear transport grouped by PYGO1-low versus PYGO1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO1→partner) and Y-score (partner→PYGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Nuclear transport →	+0.074	+1.369	.003	<.001	3	13
LUNG_SCLC	Protein localization to nucleus →	+0.060	+1.221	<.001	<.001	3	13
OESOPHAGUS	Nucleocytoplasmic transport →	+0.074	+1.369	.003	<.001	3	12
LUNG_NSCLC_LUSC	Nucleoside monophosphate biosynthetic process →	+0.086	+1.119	<.001	<.001	3	12
OESOPHAGUS	DNA-templated transcription elongation →	+0.094	+1.477	<.001	<.001	3	12
OESOPHAGUS	Transcription elongation by RNA polymerase II →	+0.113	+1.330	.002	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,918 associations by consensus.

Nuclear transport by PYGO1 expression — OESOPHAGUS

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