PYGO1

Across TCGA cell cohorts, PYGO1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PYGO1-associated genes across cancer lineages are ODF1, ZSWIM2, and OR5A1. Each is linked with PYGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGO1-to-partner and partner-to-PYGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF1 grouped by PYGO1-low versus PYGO1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO1→partner) and Y-score (partner→PYGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	1
SKIN	ZSWIM2 →	+0.067	+3.196	<.001	.007	3	1
SKIN	OR5A1 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MS4A4A →	+0.193	+4.000	<.001	.002	3	1
LARGE_INTESTINE	NPHS2 →	+0.067	+3.766	.009	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.095	+4.345	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ODF1 by PYGO1 expression — SKIN

Explore this box plot interactively →