PYGM

Across TCGA patient cohorts, PYGM mutation is significantly associated with the RNA expression of many other genes, with 4,901 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGM-associated genes across cancer lineages are ORC1, CNOT3, and EIF5AL1. Each is linked with PYGM in more than 3 cancer types. Because this analysis shows association rather than direction, both PYGM-to-partner and partner-to-PYGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ORC1 grouped by PYGM-low versus PYGM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGM→partner) and Y-score (partner→PYGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ORC1 →	+0.708	+2.828	<.001	<.001	3	4
SKCM	CNOT3 →	+0.279	+2.247	.003	.005	3	4
UCEC	EIF5AL1 →	+0.493	+2.721	.003	.003	3	4
SKCM	CRYBB2P1 →	+0.446	+2.050	<.001	.004	3	4
UCEC	PARP2 →	+0.570	+3.087	<.001	<.001	3	4
CESC	RNU6-929P →	+0.351	+4.247	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,901 associations by consensus.

ORC1 by PYGM expression — UCEC

Explore this box plot interactively →