PYGM

Across TCGA patient cohorts, PYGM mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGM-associated genes across cancer lineages are ATM, AR, and TSC1. Each is linked with PYGM in more than 2 cancer types. Because this analysis shows association rather than direction, both PYGM-to-partner and partner-to-PYGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PYGM-low versus PYGM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGM→partner) and Y-score (partner→PYGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.437	-2.209	.002	.009	3	3
UCEC	AR →	-0.308	-1.459	.010	.012	3	2
BLCA	TSC1 →	-0.194	-2.459	.047	.020	3	2
COAD	PCNA →	+0.360	+2.815	.008	.036	2	3
SKCM	c-Met →	-0.133	-2.572	.020	.010	3	2
UCEC	Cyclin-B1 →	+0.735	+2.700	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

ATM by PYGM expression — UCEC

Explore this box plot interactively →