PYGM

Across TCGA cell cohorts, PYGM RNA expression is significantly associated with the go_rna of many other GO terms, with 2,851 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PYGM-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Late viral transcription, and Regulation of RNA splicing. Each is linked with PYGM in more than 11 cancer types. Because this analysis shows association rather than direction, both PYGM-to-partner and partner-to-PYGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by PYGM-low versus PYGM-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGM→partner) and Y-score (partner→PYGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of gene expression, epigenetic →	+0.068	+0.918	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Late viral transcription →	+0.099	+0.470	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.094	+0.442	<.001	<.001	3	12
OVARY	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.119	+0.955	<.001	<.001	3	11
OVARY	Viral transcription →	+0.080	+0.729	.001	.008	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA processing →	+0.078	+0.336	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,851 associations by consensus.

Negative regulation of gene expression, epigenetic by PYGM expression — BLOOD_Lymphoma

Explore this box plot interactively →