PYGM

Across TCGA cell cohorts, PYGM mutation is significantly associated with the RNA expression of many other genes, with 105 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PYGM-associated genes across cancer lineages are OR4X2, MROH5, and LCE6A. Each is linked with PYGM in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGM-to-partner and partner-to-PYGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by PYGM-low versus PYGM-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGM→partner) and Y-score (partner→PYGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	1
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	1
SOFT_TISSUE	LCE6A →	+0.040	+5.977	<.001	.001	3	1
LARGE_INTESTINE	SIRPD →	+0.009	+2.754	.004	.009	3	1
LARGE_INTESTINE	NUDT6 →	+0.694	+3.212	.009	.006	3	1
LARGE_INTESTINE	OR10H5 →	+0.012	+2.347	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

OR4X2 by PYGM expression — SOFT_TISSUE

Explore this box plot interactively →