PYGM

Across TCGA cell cohorts, PYGM mutation is significantly associated with the mutation status of many other genes, with 3,861 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PYGM-associated genes across cancer lineages are SDK1, TNS1, and AEBP1. Each is linked with PYGM in more than 5 cancer types. Because this analysis shows association rather than direction, both PYGM-to-partner and partner-to-PYGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDK1 grouped by PYGM-low versus PYGM-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGM→partner) and Y-score (partner→PYGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SDK1 →	+3.562	+4.684	.002	.002	1	6
CNS	TNS1 →	+4.614	+4.614	.006	.006	1	5
BLOOD_Leukemia	AEBP1 →	+2.519	+2.343	.001	.001	1	5
SOFT_TISSUE	BSN →	+3.066	+4.369	.005	.005	1	5
SOFT_TISSUE	HECW2 →	+5.651	+5.651	<.001	<.001	1	5
SOFT_TISSUE	MYH14 →	+5.066	+4.502	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,861 associations by consensus.

SDK1 by PYGM expression — OVARY

Explore this box plot interactively →