PYGL

Across TCGA patient cohorts, PYGL RNA expression is significantly associated with the protein abundance of many other proteins, with 14,854 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PYGL-associated proteins across cancer lineages are PYGL_S430, ENO1, and AHNAK2. Each is linked with PYGL in more than 7 cancer types. Because this analysis shows association rather than direction, both PYGL-to-partner and partner-to-PYGL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGL versus PYGL_S430 in LSCC, with a Pearson correlation of 0.74.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGL→partner) and Y-score (partner→PYGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PYGL_S430 →	+1.219	+1.159	<.001	<.001	3	8
OV	ENO1 →	+0.385	+0.934	<.001	<.001	3	6
LSCC	AHNAK2 →	+0.934	+0.607	<.001	<.001	3	6
BRCA	AHNAK2_S260 →	+1.488	+1.595	<.001	<.001	3	6
HNSC	AHNAK2_S5175 →	+0.841	+1.075	<.001	<.001	3	6
LSCC	ERO1A →	+0.725	+0.956	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,854 associations by consensus.

PYGL vs PYGL_S430 — LSCC

Explore this scatter interactively →