PYGL

Across TCGA patient cohorts, PYGL protein abundance is significantly associated with the RNA expression of many other genes, with 20,170 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PYGL-associated genes across cancer lineages are TREM1, CXCR2, and MEDAG. Each is linked with PYGL in more than 6 cancer types. Because this analysis shows association rather than direction, both PYGL-to-partner and partner-to-PYGL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGL versus TREM1 in GBM, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGL→partner) and Y-score (partner→PYGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TREM1 →	+1.790	+0.586	<.001	<.001	3	7
LSCC	CXCR2 →	+0.974	+0.538	<.001	<.001	3	7
OV	MEDAG →	+1.422	+0.573	.004	<.001	3	7
GBM	CAV1 →	+1.600	+0.548	<.001	<.001	3	7
OV	LOXL2 →	+1.249	+0.380	<.001	.009	3	7
OV	MMP14 →	+1.311	+0.506	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,170 associations by consensus.

PYGL vs TREM1 — GBM

Explore this scatter interactively →