PYGL

Across TCGA patient cohorts, PYGL mutation is significantly associated with the RNA expression of many other genes, with 1,367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGL-associated genes across cancer lineages are CBARP, SLC7A4, and LINC01651. Each is linked with PYGL in more than 2 cancer types. Because this analysis shows association rather than direction, both PYGL-to-partner and partner-to-PYGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBARP grouped by PYGL-low versus PYGL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGL→partner) and Y-score (partner→PYGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CBARP →	+0.886	+3.828	<.001	<.001	3	3
UCEC	SLC7A4 →	-1.268	-2.775	<.001	<.001	3	3
SKCM	LINC01651 →	+0.037	+3.897	<.001	.009	3	2
SKCM	MIR3713 →	+0.184	+4.488	<.001	.003	3	2
SKCM	MIR3619 →	+0.352	+3.180	<.001	<.001	3	2
COAD	MIR34AHG →	+0.581	+3.335	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,367 associations by consensus.

CBARP by PYGL expression — UCEC

Explore this box plot interactively →