PYGL

Across TCGA patient cohorts, PYGL mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGL-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and 4E-BP1. Each is linked with PYGL in more than 2 cancer types. Because this analysis shows association rather than direction, both PYGL-to-partner and partner-to-PYGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PYGL-low versus PYGL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGL→partner) and Y-score (partner→PYGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.392	+3.008	<.001	.019	3	3
LUSC	ASNS →	+0.487	+2.816	.047	.036	3	2
COAD	4E-BP1 →	+0.250	+3.008	.028	.019	3	2
UCEC	ATM →	-0.481	-2.087	.005	.005	3	2
LUSC	eEF2 →	+0.325	+2.816	.001	.036	3	1
COAD	GAPDH →	+0.890	+3.008	<.001	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by PYGL expression — COAD

Explore this box plot interactively →