PYCR2

Across TCGA patient cohorts, PYCR2 mutation is significantly associated with the RNA expression of many other genes, with 913 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYCR2-associated genes across cancer lineages are USP9YP7, USP9YP6, and PTPN11. Each is linked with PYCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYCR2-to-partner and partner-to-PYCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP7 grouped by PYCR2-low versus PYCR2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCR2→partner) and Y-score (partner→PYCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	USP9YP7 →	+0.048	+4.567	.007	.008	3	1
STAD	USP9YP6 →	+0.043	+5.226	<.001	.003	3	1
UCEC	PTPN11 →	+0.644	+3.224	.008	.009	3	1
UCEC	ATP5F1EP2 →	+0.716	+3.475	.009	.002	3	1
UCEC	EXOC5P1 →	+0.130	+2.483	<.001	.006	3	1
UCEC	MRPS11 →	+0.496	+3.386	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 913 associations by consensus.

USP9YP7 by PYCR2 expression — STAD

Explore this box plot interactively →