PYCARD

Across TCGA patient cohorts, PYCARD mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYCARD-associated genes across cancer lineages are TRAJ55, MIR1255B2, and MTCO1P44. Each is linked with PYCARD in more than 2 cancer types. Because this analysis shows association rather than direction, both PYCARD-to-partner and partner-to-PYCARD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ55 grouped by PYCARD-low versus PYCARD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCARD→partner) and Y-score (partner→PYCARD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ55 →	+0.423	+4.868	<.001	.004	3	3
UCEC	MIR1255B2 →	+0.477	+4.750	.006	.005	3	2
HNSC	MTCO1P44 →	+0.114	+7.954	<.001	.008	3	2
KIRC	ARAFP2 →	+0.071	+7.008	<.001	<.001	3	2
BLCA	MIR4280 →	+0.350	+7.640	<.001	.009	3	2
UCEC	MIR3920 →	+0.313	+4.997	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

TRAJ55 by PYCARD expression — UCEC

Explore this box plot interactively →