PXYLP1

Across TCGA patient cohorts, PXYLP1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PXYLP1-associated genes across cancer lineages are JNK2, ACC1, and IGFBP2. Each is linked with PXYLP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PXYLP1-to-partner and partner-to-PXYLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PXYLP1-low versus PXYLP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXYLP1→partner) and Y-score (partner→PXYLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.192	+2.196	.019	.032	3	2
UCEC	ACC1 →	+0.309	+2.820	.039	.035	3	1
UCEC	IGFBP2 →	-0.715	-3.321	.007	.009	3	1
UCEC	MEK1 →	+0.461	+3.000	.002	.001	3	1
UCEC	mTOR_pS2448 →	-0.128	-1.807	.038	.027	3	1
UCEC	Notch1 →	+0.171	+2.183	.003	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

JNK2 by PXYLP1 expression — UCEC

Explore this box plot interactively →