PXYLP1

Across TCGA pan-cancer cohorts, PXYLP1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PXYLP1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PXYLP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PXYLP1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BLCA, KICH, and STAD are the cancer types where PXYLP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PXYLP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.423	<.001	11	view →
KICH	Female	All	−1.421	<.001	10	view →
STAD	Male	II,III,IV	+1.187	<.001	9	view →
COAD	Male	III,IV	+0.755	<.001	9	view →
HNSC	Male	All	+1.041	<.001	8	view →
LIHC	All	II,III,IV	+0.697	<.001	8	view →
LUSC	Female	All	+1.578	<.001	7	view →
KIRC	Male	All	+0.536	<.001	6	view →
BRCA	All	All	+0.406	<.001	6	view →
CHOL	Male	All	+1.515	<.001	5	view →
THCA	Female	All	+0.438	.004	5	view →
LUAD	All	All	+0.394	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PXYLP1–BLCA

Open the BLCA breakdown →