PXN

Across TCGA pan-cancer cohorts, PXN Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PXN data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PXN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PXN expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

COAD, OV, and UCEC are the cancer types where PXN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	IV	0.089	0.649	.005	12	view →
OV	DFS	Median	All	0.637	0.156	.040	8	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PXN–COAD (OS)

Open the COAD breakdown →