PXN-AS1

Across TCGA pan-cancer cohorts, PXN-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PXN-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PXN-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PXN-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

KIRC, KICH, and UCS are the cancer types where PXN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.755	0.867	.001	133	view →
KICH	DFS	Median	III,IV	0.208	0.951	<.001	108	view →
UCS	OS	Median	All	0.783	0.363	<.001	100	view →
COAD	DFS	Quartile	IV	0.194	0.592	<.001	72	view →
ACC	DFS	Tertile	All	0.274	0.716	<.001	69	view →
LIHC	DFS	Tertile	All	0.431	0.663	<.001	69	view →
BLCA	OS	Tertile	IV	0.172	0.441	.003	53	view →
KIRP	DFS	Tertile	All	0.585	0.782	.001	48	view →
UVM	DFS	Quartile	III,IV	0.188	0.823	<.001	46	view →
BRCA	OS	Tertile	III,IV	0.949	0.819	<.001	32	view →
LGG	OS	Quartile	All	0.503	0.375	.002	30	view →
MESO	DFS	Tertile	II,III,IV	0.150	0.744	.001	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PXN-AS1–KIRC (DFS)

Open the KIRC breakdown →