PXN-AS1

Across TCGA pan-cancer cohorts, PXN-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PXN-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PXN-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PXN-AS1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

LIHC, KICH, and COAD are the cancer types where PXN-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PXN-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.115	<.001	9	view →
KICH	Female	All	−0.916	<.001	7	view →
COAD	Female	All	+0.634	<.001	7	view →
CHOL	All	All	+1.218	<.001	4	view →
KIRP	All	II,III,IV	+0.434	.013	4	view →
STAD	Female	All	+0.404	.018	4	view →
LUSC	All	All	+0.341	.001	4	view →
BLCA	Female	III,IV	+0.591	.033	1	view →
ESCA	All	All	+0.425	.025	1	view →
HNSC	Male	III,IV	+0.409	.034	1	view →
LUAD	Female	II,III,IV	−0.407	.003	1	view →
BRCA	All	All	+0.136	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PXN-AS1–LIHC

Open the LIHC breakdown →