PXK

Across TCGA patient cohorts, PXK mutation is significantly associated with the RNA expression of many other genes, with 684 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PXK-associated genes across cancer lineages are RNA5SP422, RNA5SP412, and RTCB. Each is linked with PXK in more than 2 cancer types. Because this analysis shows association rather than direction, both PXK-to-partner and partner-to-PXK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by PXK-low versus PXK-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXK→partner) and Y-score (partner→PXK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP422 →	+0.284	+8.055	.001	.007	3	3
UCEC	RNA5SP412 →	+0.570	+1.967	<.001	.005	3	2
UCEC	RTCB →	+0.487	+2.961	.003	<.001	3	2
UCEC	GRHPR →	+0.388	+2.606	.005	<.001	3	2
UCEC	REXO4 →	+0.404	+2.871	.001	.001	3	2
LUAD	MIR4499 →	+0.938	+4.990	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 684 associations by consensus.

RNA5SP422 by PXK expression — BRCA

Explore this box plot interactively →