PXDN

Across TCGA cell cohorts, PXDN mutation is significantly associated with the RNA expression of many other genes, with 767 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PXDN-associated genes across cancer lineages are NEUROD6, CHUK, and FSCB. Each is linked with PXDN in more than 2 cancer types. Because this analysis shows association rather than direction, both PXDN-to-partner and partner-to-PXDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD6 grouped by PXDN-low versus PXDN-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXDN→partner) and Y-score (partner→PXDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NEUROD6 →	+0.030	+5.087	<.001	.004	3	3
BLOOD_Leukemia	CHUK →	+0.507	+3.321	.007	.005	3	3
OESOPHAGUS	FSCB →	+0.046	+4.906	<.001	.006	3	2
SOFT_TISSUE	GAGE12F →	+0.893	+3.635	<.001	.007	3	2
SOFT_TISSUE	OR11H12 →	+0.048	+4.637	<.001	<.001	3	2
SOFT_TISSUE	CT45A1 →	+1.710	+3.999	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 767 associations by consensus.

NEUROD6 by PXDN expression — URINARY_TRACT

Explore this box plot interactively →