PXDC1

Across TCGA pan-cancer cohorts, PXDC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PXDC1 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PXDC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PXDC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where PXDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.881	0.606	<.001	45	view →
GBM	DFS	Median	All	0.263	0.477	.002	20	view →
PDAC	OS	Tertile	II,III,IV	0.758	0.487	.006	8	view →
HNSC	DFS	Median	II,III,IV	0.886	0.702	.010	6	view →
LUAD	DFS	Median	All	0.867	1.000	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PXDC1–CCRCC (DFS)

Open the CCRCC breakdown →