PXDC1

Across TCGA pan-cancer cohorts, PXDC1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PXDC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PXDC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PXDC1 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

KIRC, BLCA, and HNSC are the cancer types where PXDC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PXDC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.429	<.001	12	view →
BLCA	All	III,IV	−1.063	<.001	11	view →
HNSC	All	III,IV	+0.891	<.001	11	view →
LUAD	Female	All	−1.224	<.001	9	view →
KICH	Female	II,III,IV	−2.495	<.001	8	view →
UCEC	All	All	−1.199	<.001	8	view →
BRCA	All	III,IV	−1.440	<.001	6	view →
LUSC	Female	II,III,IV	−1.367	<.001	6	view →
THCA	Female	All	−0.602	<.001	6	view →
LIHC	Female	All	−0.815	<.001	5	view →
CHOL	All	All	−1.049	.010	2	view →
PRAD	All	All	−0.461	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PXDC1–KIRC

Open the KIRC breakdown →