PXDC1

Across TCGA cell cohorts, PXDC1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PXDC1-associated genes across cancer lineages are OR2T8, C10orf53, and TAFA1. Each is linked with PXDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PXDC1-to-partner and partner-to-PXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T8 grouped by PXDC1-low versus PXDC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXDC1→partner) and Y-score (partner→PXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2T8 →	+0.175	+3.693	<.001	.005	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR2T8 by PXDC1 expression — LARGE_INTESTINE

Explore this box plot interactively →