PXDC1

Across TCGA cell cohorts, PXDC1 mutation is significantly associated with the mutation status of many other genes, with 2,070 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PXDC1-associated genes across cancer lineages are GRK3, DDX17, and DNTTIP1. Each is linked with PXDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PXDC1-to-partner and partner-to-PXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRK3 grouped by PXDC1-low versus PXDC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXDC1→partner) and Y-score (partner→PXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRK3 →	+2.874	+3.632	.002	.002	1	2
LARGE_INTESTINE	DDX17 →	+2.781	+4.504	<.001	<.001	1	2
LARGE_INTESTINE	DNTTIP1 →	+5.044	+4.087	.001	.001	1	2
LARGE_INTESTINE	VAPA →	+4.044	+3.744	.003	.003	1	2
LARGE_INTESTINE	KCTD9 →	+5.044	+4.087	.001	.001	1	2
LARGE_INTESTINE	HBP1 →	+5.459	+4.744	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,070 associations by consensus.

GRK3 by PXDC1 expression — LARGE_INTESTINE

Explore this box plot interactively →