PWWP3B

Across TCGA pan-cancer cohorts, PWWP3B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PWWP3B data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PWWP3B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PWWP3B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, ACC, and UCEC are the cancer types where PWWP3B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.082	0.711	<.001	51	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.953	0.419	.001	34	view →
BRCA	OS	Median	III,IV	0.001	0.907	<.001	28	view →
LGG	OS	Median	All	0.195	0.889	<.001	6	view →
BLCA	DFS	Median	All	0.127	0.594	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PWWP3B–HNSC (OS)

Open the HNSC breakdown →