PWWP3B

Across TCGA pan-cancer cohorts, PWWP3B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PWWP3B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PWWP3B RNA is repressed in tumor relative to normal tissue. In most cancer types PWWP3B is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and KICH are the cancer types where PWWP3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PWWP3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−4.596	<.001	10	view →
UCEC	All	II,III,IV	−3.110	<.001	8	view →
KICH	All	II,III,IV	−0.903	<.001	8	view →
STAD	All	All	−0.145	.004	7	view →
BLCA	All	III,IV	+1.332	.005	6	view →
LIHC	All	All	−0.441	.004	4	view →
BRCA	All	All	+0.384	.008	4	view →
COAD	Female	IV	−0.870	.011	2	view →
READ	All	All	−0.272	.019	2	view →
CHOL	Female	All	−1.263	<.001	1	view →
ESCA	All	All	−1.010	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PWWP3B–THCA

Open the THCA breakdown →