PWWP3B

Across TCGA patient cohorts, PWWP3B mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PWWP3B-associated genes across cancer lineages are FASN, PDCD4, and ATM. Each is linked with PWWP3B in more than 2 cancer types. Because this analysis shows association rather than direction, both PWWP3B-to-partner and partner-to-PWWP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PWWP3B-low versus PWWP3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP3B→partner) and Y-score (partner→PWWP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.244	+1.459	.023	.011	3	3
UCEC	PDCD4 →	-0.429	-1.633	<.001	.002	3	3
UCEC	ATM →	-0.441	-1.584	<.001	<.001	3	3
SKCM	PAI-1 →	+0.573	+2.016	.006	.015	3	3
STAD	JNK_pT183_Y185 →	-0.151	-2.978	.011	.036	3	2
UCEC	eIF4E →	+0.222	+1.765	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

FASN by PWWP3B expression — UCEC

Explore this box plot interactively →