PWWP3B

Across TCGA cell cohorts, PWWP3B mutation is significantly associated with the drug of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PWWP3B-associated genes across cancer lineages are LCL161, GSK2801, and 123829. Each is linked with PWWP3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PWWP3B-to-partner and partner-to-PWWP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by PWWP3B-low versus PWWP3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP3B→partner) and Y-score (partner→PWWP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.371	+2.868	.015	.022	3	1
LARGE_INTESTINE	GSK2801 →	+0.379	+2.871	.011	.021	3	1
LARGE_INTESTINE	123829 →	+0.587	+2.871	.033	.021	3	1
LARGE_INTESTINE	Quizartinib →	+0.441	+2.874	.003	.021	3	1
LARGE_INTESTINE	Ara-G →	+0.203	+2.865	.010	.028	3	1
LARGE_INTESTINE	RU-SKI 43 →	+0.362	+2.807	.032	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

LCL161 by PWWP3B expression — LARGE_INTESTINE

Explore this box plot interactively →