PWWP2B

Across TCGA pan-cancer cohorts, PWWP2B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PWWP2B data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PWWP2B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PWWP2B expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

PDAC, GBM, and LSCC are the cancer types where PWWP2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.405	0.701	.006	30	view →
GBM	DFS	Median	All	0.876	0.511	.012	3	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	2	view →
HNSC	DFS	Tertile	IV	0.561	0.835	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PWWP2B–PDAC (OS)

Open the PDAC breakdown →