PWWP2B

Across TCGA pan-cancer cohorts, PWWP2B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PWWP2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PWWP2B RNA is repressed in tumor relative to normal tissue. In most cancer types PWWP2B is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, LIHC, and BRCA are the cancer types where PWWP2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PWWP2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.140	<.001	11	view →
LIHC	Female	II,III,IV	+1.964	<.001	9	view →
BRCA	All	All	+0.402	<.001	6	view →
STAD	Male	All	+0.839	<.001	5	view →
THCA	All	All	+0.249	.002	4	view →
CHOL	All	All	+3.248	<.001	3	view →
KIRP	All	All	−0.747	<.001	3	view →
PRAD	All	All	+0.348	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PWWP2B–KIRC

Open the KIRC breakdown →