PWWP2B

Across TCGA patient cohorts, PWWP2B protein abundance is significantly associated with the RNA expression of many other genes, with 3,430 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PWWP2B-associated genes across cancer lineages are PPP2R2D, TBC1D12, and CACUL1. Each is linked with PWWP2B in more than 4 cancer types. Because this analysis shows association rather than direction, both PWWP2B-to-partner and partner-to-PWWP2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PWWP2B versus PPP2R2D in LSCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP2B→partner) and Y-score (partner→PWWP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP2R2D →	+0.446	+0.367	<.001	<.001	3	5
GBM	TBC1D12 →	+0.926	+0.599	.003	.002	3	4
GBM	CACUL1 →	+0.665	+0.666	<.001	.001	3	4
UCEC	ABRAXAS2 →	+0.463	+0.260	.009	<.001	3	4
BRCA	ZRANB1 →	+0.371	+0.341	.002	.002	3	4
UCEC	SLK →	+0.539	+0.242	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,430 associations by consensus.

PWWP2B vs PPP2R2D — LSCC

Explore this scatter interactively →