PWWP2B

Across TCGA patient cohorts, PWWP2B mutation is significantly associated with the RNA expression of many other genes, with 1,373 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PWWP2B-associated genes across cancer lineages are RN7SL131P, SAP30, and LINC01853. Each is linked with PWWP2B in more than 2 cancer types. Because this analysis shows association rather than direction, both PWWP2B-to-partner and partner-to-PWWP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL131P grouped by PWWP2B-low versus PWWP2B-high in ACC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP2B→partner) and Y-score (partner→PWWP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	RN7SL131P →	+0.199	+5.228	<.001	.005	3	3
UCEC	SAP30 →	+0.560	+2.021	.004	.005	3	3
ACC	LINC01853 →	+0.115	+5.662	.005	.002	3	2
ACC	MORF4L1P5 →	+0.044	+5.228	<.001	.005	3	2
UCEC	NOCT →	+0.955	+3.180	<.001	<.001	3	2
UCEC	EIF4E →	+0.416	+2.716	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,373 associations by consensus.

RN7SL131P by PWWP2B expression — ACC

Explore this box plot interactively →