PWWP2B

Across TCGA cell cohorts, PWWP2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PWWP2B-associated GO terms across cancer lineages are Regulation of fat cell differentiation, Negative regulation of Notch signaling pathway, and Protein destabilization. Each is linked with PWWP2B in more than 10 cancer types. Because this analysis shows association rather than direction, both PWWP2B-to-partner and partner-to-PWWP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fat cell differentiation grouped by PWWP2B-low versus PWWP2B-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP2B→partner) and Y-score (partner→PWWP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of fat cell differentiation →	+0.080	+1.407	<.001	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of Notch signaling pathway →	+0.095	+1.047	.001	.001	3	11
LARGE_INTESTINE	Protein destabilization →	+0.091	+1.145	<.001	<.001	3	11
URINARY_TRACT	Establishment of epithelial cell apical/basal polarity →	-0.189	-1.582	<.001	<.001	3	11
KIDNEY	Positive regulation of corticotropin secretion →	-1.478	-1.356	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Maintenance of unfolded protein →	+0.178	+1.024	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

Regulation of fat cell differentiation by PWWP2B expression — STOMACH

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