PWWP2B

Across TCGA cell cohorts, PWWP2B mutation is significantly associated with the RNA expression of many other genes, with 236 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PWWP2B-associated genes across cancer lineages are C1QL2, RGR, and UCMA. Each is linked with PWWP2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PWWP2B-to-partner and partner-to-PWWP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QL2 grouped by PWWP2B-low versus PWWP2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP2B→partner) and Y-score (partner→PWWP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1QL2 →	+0.011	+3.922	<.001	.002	3	2
BLOOD_Leukemia	RGR →	+0.022	+3.684	<.001	.004	3	2
BLOOD_Leukemia	UCMA →	+0.077	+3.926	<.001	.003	3	2
BLOOD_Leukemia	OR10Q1 →	+0.010	+3.969	.002	.009	3	2
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1
OVARY	DAO →	+0.047	+3.584	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 236 associations by consensus.

C1QL2 by PWWP2B expression — BLOOD_Leukemia

Explore this box plot interactively →