PWWP2A

Across TCGA pan-cancer cohorts, PWWP2A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PWWP2A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PWWP2A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PWWP2A expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where PWWP2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.626	0.905	.009	11	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.329	.004	10	view →
PDAC	DFS	Median	III,IV	0.412	0.875	.004	7	view →
HNSC	OS	Tertile	All	0.516	1.000	.044	6	view →
OV	DFS	Median	All	0.846	1.000	.042	4	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PWWP2A–CCRCC (DFS)

Open the CCRCC breakdown →