PWWP2A

Across TCGA patient cohorts, PWWP2A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PWWP2A-associated genes across cancer lineages are ATM, PCNA, and 4E-BP1. Each is linked with PWWP2A in more than 2 cancer types. Because this analysis shows association rather than direction, both PWWP2A-to-partner and partner-to-PWWP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PWWP2A-low versus PWWP2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP2A→partner) and Y-score (partner→PWWP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.471	-1.986	.003	.029	3	3
COAD	PCNA →	+0.406	+2.815	.002	.036	3	2
UCEC	4E-BP1 →	+0.360	+3.700	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.222	.008	.009	3	2
UCEC	mTOR_pS2448 →	-0.143	-1.662	.006	.011	3	2
UCEC	PDCD4 →	-0.572	-1.662	<.001	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by PWWP2A expression — UCEC

Explore this box plot interactively →