PWWP2A

Across TCGA cell cohorts, PWWP2A mutation is significantly associated with the RNA expression of many other genes, with 268 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PWWP2A-associated genes across cancer lineages are C20orf173, RGR, and MYL7. Each is linked with PWWP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PWWP2A-to-partner and partner-to-PWWP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf173 grouped by PWWP2A-low versus PWWP2A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWWP2A→partner) and Y-score (partner→PWWP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C20orf173 →	+0.030	+3.632	<.001	.001	3	2
BLOOD_Leukemia	RGR →	+0.036	+4.269	<.001	.002	3	2
URINARY_TRACT	MYL7 →	+0.677	+3.611	.006	.003	3	1
URINARY_TRACT	APOBEC4 →	+0.025	+3.506	<.001	.006	3	1
URINARY_TRACT	OR9A2 →	+0.019	+3.050	.003	.007	3	1
URINARY_TRACT	OTUD6A →	+0.008	+3.459	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 268 associations by consensus.

C20orf173 by PWWP2A expression — URINARY_TRACT

Explore this box plot interactively →