PWP2

Across TCGA patient cohorts, PWP2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,542 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PWP2-associated genes across cancer lineages are GATD3A, GATD3B, and MAP7D2. Each is linked with PWP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PWP2-to-partner and partner-to-PWP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PWP2 versus GATD3A in BRCA, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWP2→partner) and Y-score (partner→PWP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GATD3A →	+1.024	+0.938	<.001	<.001	3	3
LUAD	GATD3B →	-0.747	-0.487	<.001	<.001	3	3
LUAD	MAP7D2 →	+1.514	+0.475	.001	.002	3	2
UCEC	ADAMTS19-AS1 →	-1.001	-0.594	<.001	.002	3	2
BRCA	TFIP11 →	-0.572	-1.290	<.001	<.001	3	2
CCRCC	GAS5-AS1 →	-0.595	-0.457	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,542 associations by consensus.

PWP2 vs GATD3A — BRCA

Explore this scatter interactively →