PWP2

Across TCGA pan-cancer cohorts, PWP2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of PWP2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PWP2 RNA is repressed in tumor relative to normal tissue. In most cancer types PWP2 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

LUSC are the cancer types where PWP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PWP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	III,IV	−0.110	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

PWP2–LUSC

Open the LUSC breakdown →