PWP2

Across TCGA cell cohorts, PWP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,153 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PWP2-associated GO terms across cancer lineages are Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Regulation of transcription by RNA polymerase I, and rRNA transcription. Each is linked with PWP2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PWP2-to-partner and partner-to-PWP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by PWP2-low versus PWP2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PWP2→partner) and Y-score (partner→PWP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.117	+1.454	<.001	<.001	3	14
BLOOD_Lymphoma	Regulation of transcription by RNA polymerase I →	+0.098	+1.305	<.001	<.001	3	11
BONE	rRNA transcription →	+0.097	+1.510	.002	.001	3	9
BLOOD_Leukemia	Nucleosome disassembly →	+0.134	+1.430	<.001	<.001	3	9
BLOOD_Lymphoma	Positive regulation of mRNA splicing, via spliceosome →	+0.115	+1.275	<.001	<.001	3	8
BLOOD_Lymphoma	Maturation of 5.8S rRNA →	+0.081	+1.183	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,153 associations by consensus.

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by PWP2 expression — BLOOD_Lymphoma

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