PWP2

Across TCGA cell cohorts, PWP2 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PWP2-associated genes across cancer lineages are FCN2, OR10V1, and TMEM213. Each is linked with PWP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PWP2-to-partner and partner-to-PWP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by PWP2-low versus PWP2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWP2→partner) and Y-score (partner→PWP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FCN2 →	+0.043	+4.794	<.001	.001	3	2
BLOOD_Leukemia	OR10V1 →	+0.020	+4.247	<.001	.004	3	2
BLOOD_Leukemia	TMEM213 →	+0.059	+3.491	.001	.001	3	2
BLOOD_Lymphoma	CIDEA →	+0.122	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	SMIM9 →	+0.201	+5.452	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PRAMEF1 →	+0.037	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

FCN2 by PWP2 expression — STOMACH

Explore this box plot interactively →