Across TCGA patient cohorts, PVRIG mutation is significantly associated with the RNA expression of many other genes, with 620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PVRIG-associated genes across cancer lineages are MIR4727, OR5K1, and TRAJ56. Each is linked with PVRIG in more than 1 cancer types. Because this analysis shows association rather than direction, both PVRIG-to-partner and partner-to-PVRIG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVRIG→partner) and Y-score (partner→PVRIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4727 →	+0.423	+4.680	.001	.007	3	2
SKCM	OR5K1 →	+0.033	+5.797	<.001	.001	3	2
CESC	TRAJ56 →	+0.687	+5.418	<.001	.005	3	1
CESC	LINC00351 →	+0.162	+5.201	<.001	.007	3	1
UCEC	ARMCX5-GPRASP2 →	-0.446	-3.427	<.001	.005	3	1
UCEC	DOC2B →	-1.181	-2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 620 associations by consensus.

Exploration

PVRIG survival (RNA) · tumor vs normal (RNA) · all PVRIG data types