Across TCGA pan-cancer cohorts, PVRIG RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated PVRIG data layer compared with 2 for mutation status.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PVRIG RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PVRIG expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.
HNSC, COAD, and UCS are the cancer types where PVRIG RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.