Across TCGA patient cohorts, PVRIG mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PVRIG-associated genes across cancer lineages are HER2, ACVRL1, and MSH6. Each is linked with PVRIG in more than 1 cancer types. Because this analysis shows association rather than direction, both PVRIG-to-partner and partner-to-PVRIG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVRIG→partner) and Y-score (partner→PVRIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER2 →	+0.464	+2.584	.028	.011	3	1
UCEC	ACVRL1 →	-0.189	-2.584	.002	.011	3	1
UCEC	MSH6 →	-0.527	-2.999	<.001	.035	3	1
UCEC	Annexin-1 →	+0.550	+2.999	.025	.035	3	1
UCEC	S6_pS240_S244 →	+0.436	+3.000	.021	.036	3	1
UCEC	STAT3_pY705 →	-0.384	-2.999	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

PVRIG survival (RNA) · tumor vs normal (RNA) · all PVRIG data types