Across TCGA cell cohorts, PVRIG mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PVRIG-associated genes across cancer lineages are PPY, POU1F1, and OR9Q1. Each is linked with PVRIG in more than 1 cancer types. Because this analysis shows association rather than direction, both PVRIG-to-partner and partner-to-PVRIG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVRIG→partner) and Y-score (partner→PVRIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPY →	+0.212	+4.029	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	POU1F1 →	+0.028	+3.999	<.001	.003	3	2
CNS	OR9Q1 →	+0.003	+4.169	<.001	.008	3	1
BLOOD_Lymphoma	OR4K1 →	+0.053	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	DYDC1 →	+1.397	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP10-3 →	+0.018	+5.643	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

PVRIG survival (RNA) · tumor vs normal (RNA) · all PVRIG data types