PVALB

Across TCGA patient cohorts, PVALB mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PVALB-associated genes across cancer lineages are RNU4-27P, MIR6815, and GABRG3-AS1. Each is linked with PVALB in more than 1 cancer types. Because this analysis shows association rather than direction, both PVALB-to-partner and partner-to-PVALB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-27P grouped by PVALB-low versus PVALB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVALB→partner) and Y-score (partner→PVALB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU4-27P →	+0.257	+4.612	<.001	.006	3	2
LUAD	MIR6815 →	+0.342	+4.612	<.001	.006	3	2
SKCM	GABRG3-AS1 →	+0.044	+4.159	.001	.002	3	2
BRCA	MIR8081 →	+0.770	+5.841	<.001	.003	3	1
BRCA	AQP7P5 →	+0.082	+5.610	<.001	.004	3	1
LUSC	RNA5SP472 →	+0.301	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

RNU4-27P by PVALB expression — LUAD

Explore this box plot interactively →