PUS7L

Across TCGA patient cohorts, PUS7L mutation is significantly associated with the RNA expression of many other genes, with 1,596 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUS7L-associated genes across cancer lineages are VPS26C, SLC3A2, and FLYWCH1. Each is linked with PUS7L in more than 1 cancer types. Because this analysis shows association rather than direction, both PUS7L-to-partner and partner-to-PUS7L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS26C grouped by PUS7L-low versus PUS7L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS7L→partner) and Y-score (partner→PUS7L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VPS26C →	+0.369	+2.201	.002	<.001	3	2
UCEC	SLC3A2 →	+0.409	+1.931	.001	.009	3	2
UCEC	FLYWCH1 →	+0.414	+2.144	<.001	.002	3	2
UCEC	KCNAB2 →	+0.562	+3.960	<.001	<.001	3	2
UCEC	TOLLIP →	+0.340	+1.606	.003	.006	3	2
SKCM	SORCS3-AS1 →	+0.044	+3.408	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,596 associations by consensus.

VPS26C by PUS7L expression — UCEC

Explore this box plot interactively →