PUS7L

Across TCGA pan-cancer cohorts, PUS7L RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated PUS7L data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PUS7L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PUS7L expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

UVM, LIHC, and KICH are the cancer types where PUS7L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.182	0.832	<.001	44	view →
LIHC	OS	Tertile	All	0.548	0.762	<.001	44	view →
KICH	DFS	Quartile	All	0.623	1.000	.003	40	view →
KIRC	DFS	Tertile	All	0.882	0.727	.003	32	view →
LGG	OS	Quartile	All	0.840	0.947	<.001	30	view →
CESC	DFS	Tertile	III,IV	0.304	0.772	.008	24	view →
READ	OS	Median	III,IV	0.760	0.323	.005	23	view →
SARC	OS	Quartile	All	0.637	0.844	.001	20	view →
BRCA	OS	Tertile	All	0.483	0.681	.006	17	view →
HNSC	OS	Tertile	III,IV	0.539	0.788	.009	15	view →
KIRP	OS	Quartile	III,IV	0.633	0.903	.030	14	view →
ESCA	OS	Tertile	IV	0.372	0.743	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

PUS7L–UVM (DFS)

Open the UVM breakdown →