PUS7L

Across TCGA patient cohorts, PUS7L mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PUS7L-associated genes across cancer lineages are Caspase-7-cleavedD198, p27_pT198, and 14-3-3_beta. Each is linked with PUS7L in more than 2 cancer types. Because this analysis shows association rather than direction, both PUS7L-to-partner and partner-to-PUS7L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PUS7L-low versus PUS7L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUS7L→partner) and Y-score (partner→PUS7L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.696	+2.434	.001	.001	3	3
UCEC	p27_pT198 →	+0.092	+1.584	.016	.019	3	2
UCEC	14-3-3_beta →	-0.073	-2.432	.044	.018	3	1
UCEC	eEF2 →	+0.253	+2.999	.049	.035	3	1
UCEC	EGFR_pY1068 →	-0.229	-1.925	.011	.005	3	1
UCEC	EGFR →	-0.196	-2.321	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Caspase-7-cleavedD198 by PUS7L expression — UCEC

Explore this box plot interactively →